对乙酰氨基酚类与儿童行为问题有关联

Tylenol use during pregnancy linked to behavioral problems in children

      BRISTOL, Conn., Aug. 15 (合众国际社 UPI)   对乙酰氨基酚，通常被认为对怀孕期间疼痛和发热治疗是安全的。但一项新研究表明，对出生后的孩子有影响。
      研究者分析了由雅芳组织的纵向追踪研究项目中在1991和1992期间7796名母亲与子女的数据。这些数据收集了7岁孩子其母亲怀孕18和32周时使用乙酰氨基酚的情况。母亲在怀孕期间使用对乙酰氨基酚对5至7岁的儿童行为影响的数据是经对照组（未使用者）数据权重的。其中未观察到剂量、使用时间长短与效应之间的联系。
      在这些孕妇中，约53%在怀孕18周及32%在怀孕42周时使用过乙酰氨基酚，而这些孩子都与行为问题或多动症存在相关性。32周使用者的孩子还有更高相关性的情绪症状问题。
      研究人员说这项研究表明的药物和行为问题之间的关系是由于某种子宫内发育机制所造成的。但还需要更多的研究来补充，并建立之间的因果关系。
      鉴于对乙酰氨基酚在孕妇中的广泛使用，研究者说这对公共健康问题具有重要警示性。
      这项研究，发表在JAMA儿科杂志

BRISTOL, Conn., Aug. 15 (UPI) -- Acetaminophen -- most commonly in the form of Tylenol -- is generally considered a safe method of treating pain and fever during pregnancy, but new research in England suggests it has an effect on children after birth.
Behavioral problems in children ages 5 to 7 was linked to maternal use of acetaminophen during pregnancy, though researchers at the University of Bristol say the risk should be weighed against not treating health conditions of a pregnant woman.
There was no information on dose or length of time acetaminophen was used during pregnancy. Researchers say, however, the overall link between the drug and higher risk of behavioral problems is concerning.
For the study, published in the journal JAMA Pediatrics, researchers analyzed data on 7,796 mothers participating in the Avon Longitudinal Study of Parents and Children in 1991 and 1992. The study collected data on mothers and children, with information on acetaminophen use collected at 18 and 32 weeks of pregnancy, and then when children were 7 years old.
Among the women, 53 percent used acetaminophen at 18 weeks pregnant and 42 percent used it at 32 weeks. Use at either of the two times was linked to higher risk of conduct problems and hyperactivity symptoms.
Use at 32 weeks was also linked to higher odds of emotional symptoms in children, as well as increased risk of overall difficulties.
While researchers say the study indicates the link between the drug and behavioral issues is due to some type of intrauterine mechanism, they say more research is needed to flesh out the link and establish causation.
"Further studies are required to elucidate mechanisms behind this association as well as to test alternatives to a causal explanation," researchers wrote in the study. "Given the widespread use of acetaminophen among pregnant women, this can have important implications on public health advice."

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    3 西药抗感冒药
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